University proceedings. Volga region. Medical sciences

University proceedings. Volga region. Medical sciences

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Background.The purpose of the study is to investigate the effect of COVID-19 on the structure of endometrium in women who underwent spontaneous early terminationof pregnancy.Materials and methods.Thirty 30hh bikini women of childbearing age who had spontaneous abortion and COVID-19 at least 12 months before pregnancy participated in the study.

Scrapings from the uterine cavity of women with signs of uterine pregnancy underwent standard histologic wiring and were stained with hematoxylin and eosin.Results.The presence of chorionic villi and decidual tissue on histologic samples testified to the onset of pregnancy (implantation of the fetal egg into the uterine wall).Plasmatic impregnation of the endometrial vascular wall and its thickening due to increased sclerotic changes in connective tissue were predominant among pathologic changes.

Infiltration of leukocytes indicated the presence of an inflammatory reaction.All samples showed eosinophilic fibrinoid in the decidual tissue, vacuolized cells in the trophoblast, which indicated pronounced dystrophic changes in the chorionic villi.Conclusions.Probably, COVID-19 virus has a damaging effect on the endothelium of endometrial vessels, which leads to impaired trophic and intrauterine development of the fetus.

It is possible that the time-delayed effect of the virus on the endometrial vascular wall increases mel axolotl the risk of early spontaneous abortion in women who had COVID-19 within a year before pregnancy.